This study was undertaken to assess the in vitro dissolution and in vivo bioavailability of six brands of ciprofloxacin oral tablets\navailable in the UAE market using rabbits. The in vitro dissolution profiles of the six ciprofloxacin products were determined using\nthe USP dissolution paddle method. Pharmacokinetic modeling using compartmental and noncompartmental analysis was done\nto determine the pharmacokinetic parameters of ciprofloxacin after single-dose oral administration. In vitro release study revealed\nthat the amount of ciprofloxacin released in 20 minutes was not less than 80% of the labeled amount which is in accordance\nwith the pharmacopoeial requirements. All tested products are considered to be very rapid dissolving except for formulae A and\nD. Ciprofloxacin plasma concentration in rabbits was best fitted to a two-compartment open model. The lowest bioavailability\nwas determined to be for product A (93.24%) while the highest bioavailability was determined to be for product E (108.01%).\nPostmarketing surveillance is very crucial to ensure product quality and eliminating substandard products to be distributed and,\nconsequently, ensure better patient clinical outcome. The tested ciprofloxacin generic products distributed in the UAE market were\nproven to be of good quality and could be used interchangeably with the branded ciprofloxacin product.
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